CCI-006

小分子

CCI-006

C650013-5mg

5mg

≥98%

-20°C储存

超低温冰袋运输

CCI-006 is a selective inhibitor and chemosensitizer of MLL-rearranged leukemia cells, by inhibits mitochondrial respiration resulting in insurmountable mitochondrial depolarization and a pro-apoptotic unfolded protein response (UPR) in a subset of MLL-r leukemia cells Form:Solid IC50& Target:Mitochondria

CCI-006 是一种针对 MLL 重组白血病细胞的选择性抑制剂和化疗增敏剂，它能抑制线粒体呼吸，导致线粒体去极化和促进凋亡的未折叠蛋白反应（UPR）。

292053-42-0

C15H12N2O5S

332.3 g/mol

710526

COC(=O)/C(=C/C1=CC=C(O1)C2=CC=C(C=C2)S(=O)(=O)N)/C#N

methyl (E)-2-cyano-3-[5-(4-sulfamoylphenyl)furan-2-yl]prop-2-enoate

1S/C15H12N2O5S/c1-21-15(18)11(9-16)8-12-4-7-14(22-12)10-2-5-13(6-3-10)23(17,19)20/h2-8H,1H3,(H2,17,19,20)/b11-8+

VEXAKEBSBMAIOB-DHZHZOJOSA-N

COC(=O)C(=CC1=CC=C(O1)C2=CC=C(C=C2)S(=O)(=O)N)C#N

710526

DMSO : ≥ 83.33 mg/mL (250.74 mM)

1

7

5

332.047 Da

332.047 Da

132.000 Ų

23

0

620

0

1

1.9