CRT0066854

小分子

CRT0066854

C651041-5mg

5mg

≥99%

-20°C储存

超低温冰袋运输

CRT0066854 is a potent and selective atypical PKC isoenzymes inhibitor. CRT0066854 is against full-length (FL) PKCι , PKCζ , and ROCK-II kinases with IC 50 values of 132 nM, 639 nM, and 620 nM, respectively In Vitro CRT0066854 displaces a crucial Asn-Phe-Asp motif that is part of the adenosine-binding pocket and engages an acidic patch used by arginine-rich PKC substrates. CRT0066854 (0.2-1.2 μM; 6 days) is able to restore polarized morphogenesis in the dysplastic H-Ras spheroids, and the maximal proportion of spheroids with PSALs is at the lower dose of 1.2 μM. MCE has not independently confirmed the accuracy of these methods. They are for reference only. Form:Solid IC50& Target:PKCζ 639 nM (IC 50 ) ROCK2 620 nM (IC 50 )

CRT0066854 是一种强效、选择性非典型 PKC 同工酶抑制剂。CRT0066854 对全长 (FL) PKCι 、PKCζ 和 ROCK-II 激酶的 IC 50 值分别为 132 nM、639 nM 和 620 nM。

1438881-19-6

C24H25N5S

415.55 g/mol

70702288

C1CCC2=C(C1)C3=C(N=C(N=C3S2)C4=CC=NC=C4)NC[C@H](CC5=CC=CC=C5)N

(2S)-3-phenyl-1-N-(2-pyridin-4-yl-5,6,7,8-tetrahydro-[1]benzothiolo[2,3-d]pyrimidin-4-yl)propane-1,2-diamine

1S/C24H25N5S/c25-18(14-16-6-2-1-3-7-16)15-27-23-21-19-8-4-5-9-20(19)30-24(21)29-22(28-23)17-10-12-26-13-11-17/h1-3,6-7,10-13,18H,4-5,8-9,14-15,25H2,(H,27,28,29)/t18-/m0/s1

NRHASZRDWOUMFD-SFHVURJKSA-N

C1CCC2=C(C1)C3=C(N=C(N=C3S2)C4=CC=NC=C4)NCC(CC5=CC=CC=C5)N

70702288

3-phenyl-N(1)-(2-pyridin-4-yl-5,6,7,8-tetrahydrobenzo(4,5)thieno(2,3-d)pyrimidin-4-yl)-propane-1,2-diamine;CRT0066854

DMSO : 50 mg/mL (120.32 mM; Need ultrasonic)

2

6

6

415.183 Da

415.183 Da

105.000 Ų

30

0

536

0

1

4.8