CC-115 hydrochloride

CC-115盐酸盐

CC-115 hydrochloride

C654621-1ml

1ml

10mM in DMSO

干燥,-80℃储存

超低温冰袋运输

CC-115 hydrochloride is a potent and dual DNA-PK and mTOR kinase inhibitor with IC 50 s of 13 nM and 21 nM, respectively. CC-115 blocks both mTORC1 and mTORC2 signaling. In Vitro CC-115 inhibits PC-3 cells proliferation with an IC 50 of 138 nM. In a kinase selectivity assessment against a panel of 250 protein kinases at 3 μM, only one kinase other than mTOR kinase is identified with more than 50% inhibition (cFMS 57%, IC 50 =2.0 μM). Of the PI3K related kinases (PIKKs) tested, CC-115 proves to be equipotent against DNA PK (IC 50 =15 nM) and demonstrates 40 to >1000 fold selectivity against the remaining PIKKs tested; PI3K-alpha (IC 50 =0.85 μM), ATR (50% inhibition at 30 μM) and ATM (IC 50 >30 μM). The IC 50 values for CC-115 are >10 μM against a panel of CYP enzymes and >33 μM for the hERG (human ether-a-go-go-related gene) ion channel. When screened in a single point assay at 10 μM against a Cerep receptor and enzyme panel only one target is inhibited >50% (PDE3, IC 50 =0.63 μM). MCE has not independently confirmed the accuracy of these methods. They are for reference only. In Vivo CC-115 hydrochloride shows good in vivo PK profiles across multiple species with 53%, 76% and ~100% oral bioavailability in mouse, rat and dog, respectively. CC-115 is tested at lower doses of 0.25, 0.5 and 1 mg/kg bid or 1 mg/kg qd, with observed corresponding tumor volume reductions of 46%, 57%, 66% and 57% respectively. CC-115 sustains inhibition though 24 hours. At the 1 mg/kg dose CC-115 shows significant inhibition at 1 and 3 hours, CC-115 demonstrating inhibition through 10 hours. CC-115 is evaluated using both once (qd) and twice (bid) daily dosing schedules . MCE has not independently confirmed the accuracy of these methods. They are for reference only. IC50& Target:DNA-PK 13 nM (IC 50 ) mTOR 21 nM (IC 50 ) mTORC1 mTORC2 PI3Kα 852 nM (IC 50 )

CC-115 盐酸盐是一种强效的 DNA-PK 和 mTOR 激酶双重抑制剂，其 IC 50 s 分别为 13 nM 和 21 nM。CC-115 可同时阻断 mTORC1 和 mTORC2 信号传导。

1300118-55-1(DMSO)

C16H17ClN8O

372.81 g/mol

[H]Cl.O=C1CN=C2C(N1CC)=NC(C3=C(C)N=C(C4=NN=CN4)C=C3)=CN2