Chroman 1

色满 1

Chroman 1

C654723-1ml

1ml

10mM in DMSO

-80℃储存

超低温冰袋运输

Chroman 1 is a highly potent and selective ROCK inhibitor. Chroman 1 is more potent against ROCK2 ( IC 50 =1 pM) than ROCK1 ( IC 50 =52 pM). Chroman 1 also has inhibitory activity against MRCK , with an IC 50 of 150 nM In Vitro Chroman 1 (50 nM, 24 h) inhibits caspase-3/7 activation and reduces apoptosis in human pluripotent stem cells. MCE has not independently confirmed the accuracy of these methods. They are for reference only. Apoptosis AnalysisCell Line: hESCs (human pluripotent stem cells) (WA09) Concentration: 50 nM Incubation Time: 0-12 h or 24 h Result: Reduced the number of apoptotic cells, reduced caspase-3/7 activation. Western Blot AnalysisCell Line: hESCs (human pluripotent stem cells) (WA09) Concentration: 50 nM Incubation Time: 24 h Result: Partially inhibited caspase-3 activation. IC50& Target:ROCK2|1 pM (IC|50|)|ROCK1|52 pM (IC|50|)|MRCK|150 nM (IC|50|)

Chroman 1 是一种高效、选择性的 ROCK 抑制剂。Chroman 1 对 ROCK2 的抑制作用（IC 50 =1 pM）强于 ROCK1（IC 50 =52 pM）。Chroman 1 对 MRCK 也有抑制活性，IC 50 为 150 nM。

1273579-40-0(DMSO)

C24H28N4O4

436.50 g/mol

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