CDK8-IN-1

CDK8-IN-1

C655866-1ml

1ml

10mM in DMSO

-80℃储存

超低温冰袋运输

CDK8-IN-1 is a potent and selective CDK8 inhibitor with an IC 50 of 3 nM. In Vivo CDK8-IN-1 displays low systemic clearance, very good exposure and oral bioavailability. The t max is 0.25 h by PO. The mean values of C max are 9940 μg/L, 12740 μg/L by IV and PO respectively. The values of AUC are 9378, 25952 by IV and PO respectively . MCE has not independently confirmed the accuracy of these methods. They are for reference only. IC50& Target:CDK8 3 nM (IC 50 )

CDK8-IN-1 是一种强效、选择性 CDK8 抑制剂，其 IC 50 为 3 nM。

1629633-48-2(DMSO)

C11H8F3N3O

255.20 g/mol

C1=CN=CC=C1C2=CNC(=C2C(F)(F)F)C(=O)N

包含CDK，MAPK，GSK3，CLK家族