Capzimin

小分子

卡普西明

Capzimin

C656015-1ml

1ml

10mM in DMSO

-80℃储存

超低温冰袋运输

Capzimin is a potent and moderately specific proteasome isopeptidase Rpn11 inhibitor. In Vitro Capzimin (3027) shows 80-fold selectivity for Rpn11 over Csn5, 10-fold over AMSH and 6-fold over BRCC36 (IC 50 =30 μM, 4.5 μM and 2.3 μM respectively. Capzimin is screened against the NCI panel of 60 cancer cell lines. The median GI 50 is 3.3 μM. Capzimin exhibits promising activity in leukemia cells including the SR and K562 cell lines (GI 50 values of 0.67 μM and 1 μM respectively), as well as several solid tumor cell lines including NCI-H460 (non-small cell lung cancer; GI 50 = 0.7 μM) and MCF7 (breast cancer; GI 50 =1.0 μM). Immunoblotting for the processed form of caspase 3 and caspase-cleaved poly ADP-ribose polymerase in HCT116 cells confirm that Capzimin not only blocks cell growth, but also induces apoptosis. MCE has not independently confirmed the accuracy of these methods. They are for reference only. IC50& Target:Target: Rpn11

Capzimin 是一种强效、中等特异性的蛋白酶体异肽酶 Rpn11 抑制剂。

2084868-04-0(DMSO)

C30H24N6O2S4

628.81 g/mol

C1=CC2=CC(=CN=C2C(=C1)SSC3=CC=CC4=CC(=CN=C43)C(=O)NCCC5=NC=CS5)C(=O)NCCC6=NC=CS6