CCT129957, PLCγ2 抑制剂

小分子

CCT129957

C656824-1ml

1ml

Moligand™

10mM in DMSO

-80℃储存

超低温冰袋运输

CCT129957 is an indole derivative and a potent phospholipase C-γ (PLC-γ) inhibitor with an IC 50 of ~3 μM and a GC 50 of 15 μM. CCT129957 inhibits Ca 2+ release in squamous carcinoma cells at ~15 μM In Vitro The phenyl group on the left side sat in a lipophilic pocket formed of various amino acids. The predicted binding mode of CCT129957 displays a robust hydrogen bond pattern as well as a lipophilic contact. CCT129957 inhibits the cell growth of renal UO-31 and the breast T-47D cancer cell lines by ~60-70%. MCE has not independently confirmed the accuracy of these methods. They are for reference only. IC50& Target:IC50: ~3 μM (Phospholipase C-γ (PLC-γ))

CCT129957 是一种吲哚衍生物和强效磷脂酶 C-γ（PLC-γ）抑制剂，其 IC 50 约为 3 μM，GC 50 为 15 μM。CCT129957 在约 15 μM 时可抑制鳞状癌细胞中 Ca 2+ 的释放。

883098-58-6(DMSO)

C17H15N3O3

309.32 g/mol

O=C(C(N1)=CC2=C1C([N+]([O-])=O)=CC=C2)NCCC3=CC=CC=C3

抑制剂

PLCγ2 抑制剂