Compstatin TFA

康普他汀

Compstatin TFA

C659076-5mg

5mg

≥99%

避光,干燥,-80℃储存

超低温冰袋运输

Compstatin TFA, a 13-residue cyclic peptide, is a potent inhibitor of the complement system C3 with species specificity. Compstatin TFA binds to baboon C3 and is resistant to proteolytic cleavage in baboon blood (similar to humans). Compstatin TFA inhibit Appearance:Solid In Vitro:Compstatin exhibits an in vitro half-life in human blood of about 2 hr. In solution, compstatin forms a β-turn at residues Gln-5–Gly-8 with the disulfide bridge Cys-2–Cys12, residues Ile-1–Val-4, and Thr-13, forming a hydrophobic cluster. MCE ha In Vivo:Compstatin (21mg/kg) produces complete inhibition when given as a combination of bolus injection and infusion. Compstatin completely inhibits in vivo heparin/protamine-induced complement activation without adverse effects on heart rate or systemic arteri Biological Activity:Compstatin TFA, a 13-residue cyclic peptide, is a potent inhibitor of the complement system C3 with species specificity. Compstatin TFA binds to baboon C3 and is resistant to proteolytic cleavage in baboon blood (similar to humans). Compstatin TFA inhibit

C68H100F3N23O19S2

1664.79 g/mol

DMSO : 110 mg/mL (66.07 mM; Need ultrasonic) H2O : 50 mg/mL (30.03 mM; Need ultrasonic)