地美环素是由金黄色链霉菌的诱变菌株产生的金霉素四环素类似物，于1957年首次分离。与所有四环素一样，地美环素具有广谱的抗菌和原生动物活性，并通过与30S和50S核糖体亚基结合而起作用，从而阻止蛋白质合成。地氯环素已在文献中被广泛引用，有800多个参考文献几乎全部涉及体内使用。 Demeclocycline, a chlortetracycline analogue produced by a mutagenised strain of|Streptomyces aureofaciens|, was first isolated in 1957. Like all tetracyclines, demeclocycline shows broad spectrum antibacterial and antiprotozoan activity and acts by binding to the 30S and 50S ribosomal subunits, blocking protein synthesis. Demeclocycline has been extensively cited in the literature with over 800 references relating almost exclusively to in vivo use.