DKM 2-93是相对选择性的UBA5抑制剂，IC50值为430 μM。 Information DKM 2-93 DKM 2-93 is a relatively selective lead inhibitor of ubiquitin-like modifier activating enzyme 5 (UBA5) . Targets UBA5 In vitro DKM 2-93 not only impairs pancreatic cancer cell survival in PaCa2, but also Panc1 cells with 50 % effective concentration values of 90 and 30 μM, respectively. In vivo DKM 2-93 daily treatment significantly impairs tumor growth of PaCa2 cells in vivo in tumor xenograft studies in immune-deficient mice without causing any weight loss or overt toxicity. Cell Research(from reference) Cell lines：PaCa2 and Panc1 pancreatic cancer cells Incubation Time：48 h