Information DGY-06-116 DGY-06-116 is an irreversible covalent and selective inhibitor of Src with IC50 of 2.6 nM. Targets Src (Cell-free assay) 2.6 nM In vitro DGY-06-116 inhibits Src enzymatic activity. DGY-06-116 binds covalently to Src in a manner similar to SM1-71, where the p-loop must kink to establish the covalent bond.