DMU2139

小分子

DMU2139

D650441-5mg

5mg

≥98%

-20°C储存

超低温冰袋运输

DMU2139 is a potent and specific CYP1B1 inhibitor, with IC 50 s of 9 nM and 795 nM for CYP1B1 and CYP1A1, respectively. In Vitro DMU2139 (6j) shows 88 and 133-fold selectivity for CYP1B1 over CYP1A1 and CYP1A2. In the presence of DMU2139, the EC 50 is reversed back to 8.3 μM from 61 μM (seen in CYP1B1-expressing cells without any inhibitor). The EC 50 value, in the presence of DMU2139, resembles the EC 50 of cisplatin, 8.7μM, in cells transfected with the empty plasmid which has no CYP1B1 gene and therefore cannot express CYP1B1 protein. MCE has not independently confirmed the accuracy of these methods. They are for reference only. Form:Solid IC50& Target:CYP1B1 9 nM (IC 50 ) CYP1A1 795 nM (IC 50 )

DMU2139 是一种强效的特异性 CYP1B1 抑制剂，对 CYP1B1 和 CYP1A1 的 IC 50 s 分别为 9 nM 和 795 nM。

1821143-80-9

C19H15NO2

289.3 g/mol

13615899

COC1=CC2=C(C=C1)C=C(C=C2)C(=O)/C=C/C3=CN=CC=C3

(E)-1-(6-methoxynaphthalen-2-yl)-3-pyridin-3-ylprop-2-en-1-one

1S/C19H15NO2/c1-22-18-8-7-15-11-17(6-5-16(15)12-18)19(21)9-4-14-3-2-10-20-13-14/h2-13H,1H3/b9-4+

MPDPEUALCUWORP-RUDMXATFSA-N

COC1=CC2=C(C=C1)C=C(C=C2)C(=O)C=CC3=CN=CC=C3

DMSO : 77.5 mg/mL (267.86 mM; Need ultrasonic) Ethanol : 5 mg/mL (17.28 mM; Need ultrasonic)

0

3

4

289.11 Da

289.11 Da

39.200 Ų

22

0

406.000

0

1

3.800

35887544