DB1113 (Example 24) is a bifunctional compound targeted protein degradation of kinases. DB1113 degrades ABL1 , ABL2, BLK, CDK11B, CDK4 , CSK, EPHA3 , FER, GAK, LIMK1 , MAP3K20, MAP4K1, MAP4K2, MAP4K3, MAP4K5, MAPK14, MAPK7, MAPK8, MAPK9, MAPKAPK2 , MAPKAPK3, NLK, PDIK1L, PTK2B, RIPK1 , RPS6KA1, RPS6KA3, SIK2 , SIK3 , STK35, TNK2, and ULK1 . DB1113 can be used for research of disease or disorder mediated by aberrant kinase activity Form:Solid IC50& Target:CDK4 CDK11B MAP4K2 SIK2 SIK3 MAP4K5 HPK1 GLK/MAP4K3 ULK1 LIMK1