Duocarmycin TM

小分子

多卡米星

Duocarmycin TM

D650738-5mg

5mg

≥98%

-20°C储存

超低温冰袋运输

Duocarmycin TM (CBI-TMI) is a potent antitumor antibiotic . Duocarmycin TM induces a sequence-selective alkylation of duplex DNA. In Vitro Duocarmycin TM (60 μM; 4 d; BJAB and WSU-DLCL2 cells) is a cytotoxic agent that inhibits the proliferation of tumor cells. MCE has not independently confirmed the accuracy of these methods. They are for reference only. Cell Viability AssayCell Line: BJAB and WSU-DLCL2 cells Concentration: 60 μM Incubation Time: 4 days Result: Inhibited the proliferation of tumor cells with IC 50 values of 0.153 μM and 0.079μM for BJAB and WSU-DLCL2 cells, respectively. Form:Solid IC50& Target:Duocarmycins

Duocarmycin TM（CBI-TMI）是一种强效抗肿瘤抗生素。Duocarmycin TM 可诱导双链 DNA 发生序列选择性烷基化。

157922-77-5

C25H23ClN2O5

466.91 g/mol

394851

COC1=C(C(=C2C(=C1)C=C(N2)C(=O)N3C[C@H](C4=C3C=C(C5=CC=CC=C54)O)CCl)OC)OC

[(1S)-1-(chloromethyl)-5-hydroxy-1,2-dihydrobenzo[e]indol-3-yl]-(5,6,7-trimethoxy-1H-indol-2-yl)methanone

1S/C25H23ClN2O5/c1-31-20-9-13-8-17(27-22(13)24(33-3)23(20)32-2)25(30)28-12-14(11-26)21-16-7-5-4-6-15(16)19(29)10-18(21)28/h4-10,14,27,29H,11-12H2,1-3H3/t14-/m1/s1

NRHDGIYFJJUFKN-CQSZACIVSA-N

COC1=C(C(=C2C(=C1)C=C(N2)C(=O)N3CC(C4=C3C=C(C5=CC=CC=C54)O)CCl)OC)OC

394851

DMSO : ≥ 50 mg/mL (107.09 mM)

2

5

5

466.13 Da

466.13 Da

84.000 Ų

33

0

712

0

1

4.6

698927