10β,17β-dihydroxyestra-1,4-dien-3-one

10β,17β-二羟基雌甾-1,4-二烯-3-酮

UR9WW8CA3J | A-dihydroxyestra-1,4-dien-3-one | DTXSID501337122 | AKOS040732235 | HY-128976 | p-Estraquinol, 17beta-hydroxy- | Estra-1,4-dien-3-one, 10,17-dihydroxy-, (17beta)- | ESTRA-1,4-DIEN-3-ONE, 10,17-DIHYDROXY-, (17.BETA.)- | 10beta,17beta-dihydroxy

10β,17β-dihydroxyestra-1,4-dien-3-one

D651492-5mg

5mg

≥98%

-20°C储存

超低温冰袋运输

10β,17β-dihydroxyestra-1,4-dien-3-one (DHED) is a brain-targeting bioprecursor proagent of the main human estrogen , 17β-estradiol, alleviates hot flushes in rat models of thermoregulatory dysfunction of the brain. In Vivo 10β,17β-dihydroxyestra-1,4-dien-3-one (DHED), is an inactive bioprecursor prodrug of 17β-estradiol converting to 17β-estradiol only in the brain. DHED as an E2-bioprecursor may be a viable approach for delivering E2 selectively into the brain for the potential treatment of hot flushes . MCE has not independently confirmed the accuracy of these methods. They are for reference only. Form:Solid

10β,17β-二羟基雌甾-1,4-二烯-3-酮（DHED）是人类主要雌激素 17β-estradiol 的一种脑靶向生物前体，它能缓解大鼠脑体温调节功能障碍模型中的潮热症状。

549-02-0

C18H24O3

288.38 g/mol

11851170

C[C@]12CC[C@H]3[C@H]([C@@H]1CC[C@@H]2O)CCC4=CC(=O)C=C[C@]34O

(8S,9S,10S,13S,14S,17S)-10,17-dihydroxy-13-methyl-6,7,8,9,11,12,14,15,16,17-decahydrocyclopenta[a]phenanthren-3-one

1S/C18H24O3/c1-17-8-7-15-13(14(17)4-5-16(17)20)3-2-11-10-12(19)6-9-18(11,15)21/h6,9-10,13-16,20-21H,2-5,7-8H2,1H3/t13-,14-,15-,16-,17-,18+/m0/s1

UIKDFTLKOKNUJP-UGDFAFBOSA-N

CC12CCC3C(C1CCC2O)CCC4=CC(=O)C=CC34O

11851170

DMSO : 100 mg/mL (346.76 mM; Need ultrasonic)

2

3

0

288.173 Da

288.173 Da

57.500 Ų

21

0

549.000

0

1

1.700

NONHforallmodesoftransport