DMU2105

小分子

DMU2105

D651729-5mg

5mg

≥99%

-20°C储存

超低温冰袋运输

DMU2105 is a potent and specific CYP1B1 inhibitor, with IC 50 s of 10 nM and 742 nM for CYP1B1 and CYP1A1, respectively. In Vitro DMU2105 (Compound 7k) shows 74 and 120-fold selectivity for CYP1B1 over CYP1A1 and CYP1A2. In the presence of DMU2105 however, the EC 50 goes down to 1 μM indicating that the cells have suffered from toxicity which may have been mediated by CYP1B1 inhibition. Un-transfected cells (HEK293: pcDNA3.1), when treated with cisplatin and DMU2105 (10×IC 50 ) do not show any perceptible decrease of cisplatin EC 50 (8.5 μM ± 0.9). MCE has not independently confirmed the accuracy of these methods. They are for reference only. Form:Solid IC50& Target:CYP1B1 10 nM (IC 50 ) CYP1A1 742 nM (IC 50 )

DMU2105 是一种强效的特异性 CYP1B1 抑制剂，对 CYP1B1 和 CYP1A1 的 IC 50 s 分别为 10 nM 和 742 nM。

1821143-79-6

C18H13NO

259.30 g/mol

8854335

C1=CC=C2C=C(C=CC2=C1)/C=C/C(=O)C3=CN=CC=C3

(E)-3-naphthalen-2-yl-1-pyridin-3-ylprop-2-en-1-one

1S/C18H13NO/c20-18(17-6-3-11-19-13-17)10-8-14-7-9-15-4-1-2-5-16(15)12-14/h1-13H/b10-8+

VWBDGXJRQZDLRV-CSKARUKUSA-N

C1=CC=C2C=C(C=CC2=C1)C=CC(=O)C3=CN=CC=C3

DMSO : 33.33 mg/mL (128.54 mM; ultrasonic and warming and heat to 60°C)

0

2

3

259.1 Da

259.1 Da

30.000 Ų

20

0

362.000

0

1

3.900

35887540