DCVC

小分子

DCVC

D651785-5mg

5mg

≥99%

-20°C储存

超低温冰袋运输

DCVC (S-[(1E)-1,2-dichloroethenyl]--L-cysteine) is a bioactive metabolite of trichloroethylene (TCE). DCVC inhibits pathogen-stimulated pro-inflammatory cytokines IL-1β, IL-8 , and TNF-α release from tissue cultures. In Vitro Extraplacental membranes are cultured for 4, 8, and 24h with the trichloroethylene (TCE) metabolite S-(1,2-dichlorovinyl)-l-cysteine (DCVC) in the absence or presence of lipoteichoic acid (LTA) or lipopolysaccharide (LPS) to simulate infection. In addition, membranes were cocultured with DCVC and Group B Streptococcus (GBS). DCVC (5-50μM) significantly inhibited LTA-, LPS-, and GBS-stimulated cytokine release from tissue cultures as early as 4h. DCVC inhibits pathogen-stimulated cytokine (IL-1β, IL-8, and TNF-α) release in a concentration-dependent manner. MCE has not independently confirmed the accuracy of these methods. They are for reference only. Form:Solid

DCVC（S-[(1E)-1,2-二氯乙烯基]--L-半胱氨酸）是三氯乙烯（TCE）的一种生物活性代谢物。DCVC 可抑制组织培养物在病原体刺激下释放的促炎细胞因子 IL-1β、IL-8 和 TNF-α。

13419-46-0

C5H7Cl2NO2S

216.09 g/mol

16738704

C([C@@H](C(=O)O)N)S/C(=C\Cl)/Cl

C([C@@H](C(=O)O)N)S/C(=C\Cl)/Cl

16738704

DMSO : 2.5 mg/mL (11.57 mM; Need ultrasonic) H2O : 1.034 mg/mL (4.79 mM; Need ultrasonic and warming)

2

4

4

214.957 Da

214.957 Da

88.600 Ų

11

0

174

0

1

-1.1