DBPR108, 二肽基肽酶 IV 抑制剂

小分子

DBPR108

D656743-1ml

1ml

10mM in DMSO

-80℃储存

超低温冰袋运输

DBPR108 is a potent, selective, and orally bioavailable dipeptide-derived inhibitor of DPP4 with IC50 of 15 nM; no inhibition on DDP8 and DPP9.IC50 value: 15 nM Target: DPP4 inhibitorDBPR108 is an IC50=15 nM DPP IV inhibitor displays a more than 3000-fold selectivity over DPP8 DPP9, FAP and DPP-II. TThe in vivo effects of DBPR108, including inhibition of plasma DPP-IV activity and suppression of blood glucose elevation, were also demonstrated. DBPR108 is a potent, selective, long-acting and safe DPP-IV inhibitor as a potential treatment of type 2 diabetesmellitus.

DBPR108 是一种强效、选择性和口服生物可用的二肽衍生型 DPP4 抑制剂，其 IC50 值为 15 nM；对 DDP8 和 DPP9 没有抑制作用：DBPR108是一种IC50=15 nM的DPP IV抑制剂，对DDP8和DPP9没有抑制作用。

1186426-66-3(DMSO)

C16H25FN4O2

324.39 g/mol

CC(C)(CC(=O)N1CCCC1)NCC(=O)N2CC(CC2C#N)F

抑制剂

二肽基肽酶 IV 抑制剂