Dot1L-IN-1 TFA

Dot1L-IN-1 TFA

D658712-5mg

5mg

≥98%

-20°C储存

超低温冰袋运输

Dot1L-IN-1 TFA is a highly potent and selective Dot1L inhibitor with a K i of 2 pM and an IC 50 of Appearance:Solid IC50& Target:DOT1L In Vitro:Dot1L-IN-1 (analogue 7) TFA effectively inhibits proliferation of the human MLL-rearranged leukemia cell line MV4-11 carrying the oncogenic MLL-AF4 fusion (IC 50 =5 nM). MCE has not independently confirmed the accuracy of these methods. They are for Biological Activity:Dot1L-IN-1 TFA is a highly potent and selective Dot1L inhibitor with a K i of 2 pM and an IC 50 of

C34H37ClF3N9O4S

760.23 g/mol

CC1=NC=CC=C1C2=C(Cl)SC3=CC=C(NC(NCC(NCCCN(C)[C@@H]4CCCN(C5=C(C=CN6)C6=NC=N5)C4)=O)=O)C=C32.OC(C(F)(F)F)=O

DMSO : 50 mg/mL (65.77 mM; Need ultrasonic)