DPM-1001 trihydrochloride

DPM-1001 三盐酸盐

DPM-1001 trihydrochloride

D659068-5mg

5mg

≥98%

2-8°C储存,充氩

冰袋运输

DPM-1001 trihydrochloride is a potent, specific, orally active and non-competitive inhibitor of protein-tyrosine phosphatase (PTP1B) with an IC 50 of 100 nM. DPM-1001 trihydrochloride is an analog of the specific PTP1B inhibitor MSI-1436. DPM-1001 trihydr Appearance:Solid In Vitro:DPM-1001 trihydrochloride inhibits the short form of PTP1B reversibly, whereas PTP1B(1–405) remained inactive over an extended period of time. DPM-1001 is against PTP1B(1–405) with no pre-incubation, the IC 50 value for PTP1B(1–405) is 600 nM. However, af In Vivo:DPM-1001 trihydrochloride (oral or intraperitoneal administration; 5mg/kg; once daily; 50 days) inhibits diet-induced obesity in mice by improving insulin and leptin signaling. DPM-1001 trihydrochloride-treated, high-fat diet-fed mice starts losing weigh Biological Activity:DPM-1001 trihydrochloride is a potent, specific, orally active and non-competitive inhibitor of protein-tyrosine phosphatase (PTP1B) with an IC 50 of 100 nM. DPM-1001 trihydrochloride is an analog of the specific PTP1B inhibitor MSI-1436. DPM-1001 trihydr

C35H60Cl3N3O3

677.23 g/mol

O[C@H]1[C@]2([H])[C@](CC[C@]3(C)[C@@]2([H])CC[C@@]3([H])[C@H](C)CCC(OC)=O)([H])[C@]4(C)[C@@](C[C@H](NCCCCNCC5=CC=CC=N5)CC4)([H])C1.Cl.Cl.Cl

DMSO : 80 mg/mL (118.13 mM; Need ultrasonic) H2O : 33.33 mg/mL (49.22 mM; ultrasonic and warming and heat to 60°C)