应用 （1,3-二氧戊环-2-基甲基）溴化镁是一种格氏试剂，可用于制备：3-[11C]-丙醛，一种用于合成放射标记化合物[11C]SN-38的关键中间体，其中SN-38代表7-乙基-10-羟基喜树碱。通过与D-甘油醛反应制备1-[(S)-2,2-二甲基-(1,3)-二氧戊环-4-基]-4-(1,3-二氧戊环2-基)-2-醇，其可进一步被用于合成不饱和核苷。一种双环羧酸盐中间体，可用于spirovibsanin A的全合成。 Description (1,3-Dioxolan-2-ylmethyl)magnesium bromide is a Grignard reagent that can be used to prepare:3-[11C]-Propionaldehyde, a key intermediate for the synthesis of radiolabeled compound [11C]SN-38, wherein SN-38 is 7-ethyl-10-hydroxy camptothecin.1-[(S)-2,2-Dimethyl-(1,3)-dioxolan-4-yl]-4-(1,3-dioxolan2-yl)-2-ol by reacting with D-glyceraldehyde, which is further used to synthesize unsaturated nucleosides.A bicyclo carboxylate intermediate, which is employed in the total synthesis of spirovibsanin A.