EMT inhibitor-1

EMT抑制剂-1

EMT inhibitor-1

E649856-5mg

5mg

≥99%

-20°C储存

超低温冰袋运输

EMT inhibitor-1 is an inhibitor of of Hippo , TGF-β , and Wnt signaling pathways with antitumor activities. In Vitro EMT inhibitor-1 (C19) (0-10μM; 24 hours) is an inhibitor of of Hippo, TGF-β, and Wnt signaling pathways with antitumor activities, inhibiting cancer cell migration, proliferation, and resistance to doxorubicin in vitro. MCE has not independently confirmed the accuracy of these methods. They are for reference only. In Vivo EMT inhibitor-1 (C19) (intraperitoneal injection; 5-20 mg/kg) exerts strong antitumor activity in a mouse tumor model. Mechanistically, EMT inhibitor-1 induces GSK3-β–mediated degradation of the Hippo transducer TAZ, through activation of the Hippo kinases Mst/Lats and the tumor suppressor kinase AMPK upstream of the degradation complex .C19 is dissolved in the vehicle solution (100 μL of DMEM containing 5% dimethyl sulfoxide). MCE has not independently confirmed the accuracy of these methods. They are for reference only. Form:Solid IC50& Target:Hippo, TGF-β, Wnt

EMT 抑制剂-1 是一种具有抗肿瘤活性的 Hippo、TGF-β 和 Wnt 信号通路抑制剂。

1638526-21-2

C12H12Cl2N2O2S

319.21 g/mol

90718214

C1=CC(=C(C=C1C2=NSN=C2OCCCCO)Cl)Cl

4-[[4-(3,4-dichlorophenyl)-1,2,5-thiadiazol-3-yl]oxy]butan-1-ol

1S/C12H12Cl2N2O2S/c13-9-4-3-8(7-10(9)14)11-12(16-19-15-11)18-6-2-1-5-17/h3-4,7,17H,1-2,5-6H2

FWMUIOJZHOPPDX-UHFFFAOYSA-N

C1=CC(=C(C=C1C2=NSN=C2OCCCCO)Cl)Cl

90718214

DMSO : ≥ 100 mg/mL (313.27 mM)

1

5

6

318 Da

318 Da

83.500 Ų

19

0

276

0

1

3.6