Emprumapimod hydrochloride

盐酸恩普莫德

Emprumapimod hydrochloride

E658976-1mg

1mg

2-8°C储存,干燥

冰袋运输

Emprumapimod (PF-07265803) hydrochloride is an orally active and selective inhibitor of p38α MAPK . Emprumapimod hydrochloride can be used for the research of dilated cardiomyopathy and acute inflammatory pain. Appearance:Solid IC50& Target:p38α In Vitro:Emprumapimod hydrochloride (ARRY-797) inhibits LPS-induced IL-6 production in RPMI-8226 cell with an IC 50 value of 100 pM. MCE has not independently confirmed the accuracy of these methods. They are for reference only. In Vivo:Emprumapimod hydrochloride (ARRY-797) (30mg/kg; p.o.) inhibits the expression of IL-6 (91%) and TNF-α (95%) in SCID-beige mice, inhibits the phosphorylation of p38 in RPMI-8226 xenografts, inhibits the growth of RPMI-8226 tumour (72%) in multiple myeloma Biological Activity:Emprumapimod (PF-07265803) hydrochloride is an orally active and selective inhibitor of p38α MAPK . Emprumapimod hydrochloride can be used for the research of dilated cardiomyopathy and acute inflammatory pain .

C24H30ClF2N5O3

509.98 g/mol

CC(C)CN1C2=CC(C(N[C@H](C(N)=O)CCN(C)C)=O)=C(OC3=C(C=C(C=C3)F)F)C=C2C=N1.[H]Cl

包含CDK，MAPK，GSK3，CLK家族