Ethyl nitroacetate has been used in: · synthesis of γ-oxoacids via Michael addition reaction with α,β-unsaturated ketones · fuctionalization of C4-position on pyrimidine and C6-position on 2′-deoxyguanosine to produce novel nucleosides · facile synthesis of α,α-diisobutylglycine · synthesis of DL-4,4-difluoroglutamic acid