三磷酸氟达拉滨三钠盐

F-ara-ATP trisodium

Fludarabine triphosphate trisodium

F659287-5mg

5mg

Moligand™

≥95%

避光,-20°C储存,充氩

超低温冰袋运输

三磷酸氟达拉滨三钠盐是 Fludarabine (HY-B0069) 的活性代谢物，是一种有效的、非竞争性的、特异性的DNA引发酶 (DNA primase) 抑制剂，其 IC50 为 2.3 μM，Ki 为 6.1 μM。Fludarabine triphosphate trisodium 通过阻断 DNA 引发酶和引物 RNA 形成抑制 DNA 合成 (DNA synthesis)。Fludarabine triphosphate trisodium 可抑制核糖核苷酸还原酶和DNA聚合酶，最终导致细胞凋亡 (apoptosis)。 Fludarabine triphosphate (F-ara-ATP) trisodium, the active metabolite of Fludarabine (HY-B0069), is a potent, noncompetitive and specific inhibitor of DNA primase, with an IC50 of 2.3 μM and a Ki of 6.1 μM. Fludarabine triphosphate trisodium inhibits DNA synthesis by blocking DNA primase and primer RNA formation. Fludarabine triphosphate trisodium inhibits ribonucleotide reductase and DNA polymerase and ultimately leads to cellular apoptosis.

74832-57-8(free base)

C10H12FN5Na3O13P3

591.12 g/mol

H2O : 125 mg/mL (211.46 mM; Need ultrasonic)