Fludarabine is a purine analog included in the category of DNA-damaging drμgs with well-known efficacy in B-cell chronic lymphocytic leukemia (B-CLL).胸苷和脱氧腺苷的类似物，能与dATP竞争结合并整合入DNA中，可抑制DNA合成。 Fludarabine is a purine analog included in the category of DNA-damaging drugs with well-known efficacy in B-cell chronic lymphocytic leukemia (B-CLL). Fludarabine Phosphate is an analogue of adenosine and deoxyadenosine, which is able to compete with dATP for incorporation into DNA and inhibit DNA synthesis.