鸟苷3'，5'-环一磷酸酯是重要的第二信使，它是细胞外信号（如一氧化氮和利尿钠肽）的主要细胞内介体。与三种类型的细胞内受体蛋白相互作用：cGMP依赖性蛋白激酶，cGMP调节的通道和cGMP调节的环状核苷酸磷酸二酯酶。 Guanosine 3',5'-cyclic monophosphate is an important second messenger which is a major intracellular mediator of extracellular signals such as nitric oxide and natriuretic peptides. Interacts with three types of intracellular receptor proteins: cGMP-dependent protein kinases, cGMP-regulated channels, and cGMP-regulated cyclic nucleotide phosphodiesterases.