GW280264X

GW280264X

G646226-5mg

5mg

≥98%

-20°C储存

超低温冰袋运输

GW280264X is the mixed ADAM10/TACE (ADAM17) metalloproteinases inhibitor. GW280264X potently blocks TACE (ADAM17) and ADAM10 with IC 50 s of 8.0 nM and 11.5 nM, respectively ADAM10 and 17 modulate the immunogenicity of glioblastoma-initiating cells . In Vitro The proliferation of GS-7 cells was significantly reduced upon treatment with GW280264X or ADAM10/17 co-knockdown. MCE has not independently confirmed the accuracy of these methods. They are for reference only. Cell Viability AssayCell Line: Glioblastoma-initiating cells (GIC) GS-7 cells Concentration: 0.1, 1, and 3 µM Incubation Time: 48 hours Result: Proliferation of GIC is inhibited through inhibition of ADAM10 and ADAM17. In Vivo Pharmacological inhibition of ADAM10 and ADAM17 improves functional recovery after spinal cord injury (SCI). MCE has not independently confirmed the accuracy of these methods. They are for reference only. Animal Model: C57BL/6 miceDosage: 100 µg/kg Administration: I.p. injected; every day for one week starting 4 h post-surgery Result: Showed significantly improved functional recovery compared to the control group. Form:Solid IC50& Target:ADAM17 8 nM (IC 50 ) ADAM10 11.5 nM (IC 50 )

GW280264X 是 ADAM10/TACE (ADAM17) 金属蛋白酶混合抑制剂。GW280264X 能有效阻断 TACE（ADAM17）和 ADAM10，其 IC 50 s 分别为 8.0 nM 和 11.5 nM。ADAM10 和 17 可调节胶质母细胞瘤诱导细胞的免疫原性

866924-39-2

C28H41N5O6S

575.72 g/mol

91885425

CCC[C@@H]([C@@H](CC(C)C)C(=O)N[C@@H](CCCCNC(=O)OCC1=CC=CC=C1)C(=O)NC2=NC=CS2)N(C=O)O

benzyl N-[(5S)-5-[[(2R,3S)-3-[formyl(hydroxy)amino]-2-(2-methylpropyl)hexanoyl]amino]-6-oxo-6-(1,3-thiazol-2-ylamino)hexyl]carbamate

1S/C28H41N5O6S/c1-4-10-24(33(38)19-34)22(17-20(2)3)25(35)31-23(26(36)32-27-29-15-16-40-27)13-8-9-14-30-28(37)39-18-21-11-6-5-7-12-21/h5-7,11-12,15-16,19-20,22-24,38H,4,8-10,13-14,17-18H2,1-3H3,(H,30,37)(H,31,35)(H,29,32,36)/t22-,23+,24+/m1/s1

SKJLITFHSZNZMQ-SGNDLWITSA-N

CCCC(C(CC(C)C)C(=O)NC(CCCCNC(=O)OCC1=CC=CC=C1)C(=O)NC2=NC=CS2)N(C=O)O

91885425

DMSO : 125 mg/mL (217.12 mM; ultrasonic and warming and heat to 60°C)

4

8

18

575.278 Da

575.278 Da

178.000 Ų

40

0

782.000

0

1

4.100