GDP366

小分子

GDP366

G646840-5mg

5mg

≥99%

-20°C储存

超低温冰袋运输

GDP366, a dual inhibitor of survivin and Op18 , induces cell growth inhibition, cellular senescence and mitotic catastrophe in human cancer cells. In Vitro GDP366 potently and selectively inhibits the expression of both survivin and Op18. GDP366 decreass both the mRNA and protein levels of survivin and Op18. This inhibitory effect is not dependent on the status of p53 and p21 although GDP366 potently increases p53 and p21 levels. GDP366 significantly inhibits the growth of tumor cells in vitro and in vivo (nude mouse model) without rapid induction of apoptosis. GDP366 induces polyploidy in multiple types of cancer cell lines. GDP366 increases chromosomal instability, and induces cellular senescence by inhibiting telomerase activity. MCE has not independently confirmed the accuracy of these methods. They are for reference only. Form:Solid IC50& Target:Survivin, Op18

GDP366 是一种存活素和 Op18 的双重抑制剂，可诱导人类癌细胞的细胞生长抑制、细胞衰老和有丝分裂灾难。

501698-03-9

C20H17N5OS

375.4 g/mol

6539985

CC1=CC(=CC=C1)NC(=O)NC2=CC=C(C=C2)C3=CSC4=NC=NC(=C34)N

1-[4-(4-aminothieno[2,3-d]pyrimidin-5-yl)phenyl]-3-(3-methylphenyl)urea

1S/C20H17N5OS/c1-12-3-2-4-15(9-12)25-20(26)24-14-7-5-13(6-8-14)16-10-27-19-17(16)18(21)22-11-23-19/h2-11H,1H3,(H2,21,22,23)(H2,24,25,26)

DZSUJUOJJJCWGG-UHFFFAOYSA-N

CC1=CC(=CC=C1)NC(=O)NC2=CC=C(C=C2)C3=CSC4=NC=NC(=C34)N

6539985

GDP 366;GDP-366;GDP366

DMSO : 62.5 mg/mL (166.47 mM; Need ultrasonic)

3

5

3

375.115 Da

375.115 Da

121.000 Ų

27

0

513

0

1

3.8