GSM-1

小分子

4-Piperidineacetic acid, 1-((1R)-1-(4-chlorophenyl)-4-methylpentyl)-2-(4-(trifluoromethyl)phenyl)-,(2S,4R)- | SCHEMBL2855563 | (2S)-1-((.ALPHA.R)-.ALPHA.-(3-METHYLBUTYL)-4-CHLOROBENZYL)-2.ALPHA.-(4-(TRIFLUOROMETHYL)PHENYL)PIPERIDINE-4.ALPHA.-ACETIC ACID |

GSM-1

G651216-5mg

5mg

≥98%

-20°C储存

超低温冰袋运输

GSM-1 is a potent γ-secretase modulator. GSM-1 directly targets the transmembrane domain (TMD) 1 of presenilin 1 (PS1). In Vitro GSM-1 increases the levels of Aβ 38 produced from WT APP. GSM-1 potently loweres the levels of Aβ 42 of WT APP and all the Phe mutants by ∼70–80%, even for the V44F mutant, which produced only extremely small amounts of Aβ 42. GSM-1 directly binds to the N-terminal fragment of PS1. MCE has not independently confirmed the accuracy of these methods. They are for reference only. Form:Solid

GSM-1 是一种强效的γ-分泌酶调节剂。GSM-1 直接靶向 presenilin 1（PS1）的跨膜域（TMD）1。

884600-68-4

C26H31ClF3NO2

481.98 g/mol

57987388

CC(C)CC[C@H](C1=CC=C(C=C1)Cl)N2CC[C@H](C[C@H]2C3=CC=C(C=C3)C(F)(F)F)CC(=O)O

2-[(2S,4R)-1-[(1R)-1-(4-chlorophenyl)-4-methylpentyl]-2-[4-(trifluoromethyl)phenyl]piperidin-4-yl]acetic acid

1S/C26H31ClF3NO2/c1-17(2)3-12-23(19-6-10-22(27)11-7-19)31-14-13-18(16-25(32)33)15-24(31)20-4-8-21(9-5-20)26(28,29)30/h4-11,17-18,23-24H,3,12-16H2,1-2H3,(H,32,33)/t18-,23-,24+/m1/s1

VMVWLAPASRQXFL-QFWMQHCXSA-N

CC(C)CCC(C1=CC=C(C=C1)Cl)N2CCC(CC2C3=CC=C(C=C3)C(F)(F)F)CC(=O)O

57987388

884600-68-4

DMSO : 100 mg/mL (207.48 mM; Need ultrasonic)

1

6

8

481.2 Da

481.2 Da

40.500 Ų

33

0

613

0

1

4.8