GDC-0276

小分子

GDC-0276

G651312-5mg

5mg

≥99%

-20°C储存

超低温冰袋运输

GDC-0276 is a potent, selective, reversible and orally active NaV1.7 inhibitor with an IC 50 value of 0.4 nM. GDC-0276 is well tolerated and exhibits a good pharmacokinetic profile. GDC-0276 has the potential for the treatment of pain and to address shortcomings of existing pain medications, such as addiction and off-target side effects In Vivo GDC-0276 (oral adminstration; 0.5-5 mg/kg) shows enrichment of 14 C with observed specific activities of 22.6 µCi/mg. GDC-0276 is not detected in urine; however, metabolites in urine were enriched in 14 C with observed specific activities of 19.6 µCi/mg. MCE has not independently confirmed the accuracy of these methods. They are for reference only. Animal Model: Six drug-naïve beagle dogs Group 1 four dogs (n=2 per sex) and Group 2 2 BDC dogs (n=2 male)Dosage: 0.5, 1, 2, 3, 4, 5 mg/kg Administration: Oral adminstration Result: Showed mean specific activities of 12.2 µCi/mg (a 24% enrichment) (n=4 animals) and 23.5 µCi/mg (a 139% enrichment) (n=2 animals) for Groups 1 and 2, respectively. Form:Solid IC50& Target:Nav1.7

GDC-0276 是一种强效、选择性、可逆和口服活性 NaV1.7 抑制剂，其 IC 50 值为 0.4 nM。GDC-0276 具有良好的耐受性和药代动力学特征。GDC-0276 有可能用于治疗疼痛和解决短时疼痛。

1494581-70-2

C24H31FN2O4S

462.58 g/mol

O=C(NS(=O)(N1CCC1)=O)C2=CC(C3CC3)=C(OCC4(C5)CC6CC5CC(C6)C4)C=C2F

DMSO : 125 mg/mL (270.22 mM; Need ultrasonic)