GNE-131, Na 抑制剂 v1.1；Na 抑制剂 v1.2；Na 抑制剂 v1.5；Na 抑制剂 v1.6；Na 抑制剂 v1.7

小分子

GNE-131

G654724-1ml

1ml

Moligand™

10mM in DMSO

-80℃储存

超低温冰袋运输

GNE-131 是有效的人类钠离子通道 NaV1.7(hNaV1.7)选择性抑制剂，IC50为 3 nM GNE-131 is a potent and selective inhibitor of human sodium channel NaV1.7 , with an IC 50 of 3 nM. In Vitro GNE-131 (Compound 13) shows moderate clearance in human liver microsomes and excellent functional activity against human NaV1.7 with an IC 50 of 0.003±0.001 μM. GNE-131 shows excellent potency, good in vitro metabolic stability. MCE has not independently confirmed the accuracy of these methods. They are for reference only. In Vivo GNE-131 shows low in vivo clearance in mouse, rat, and dog. GNE-131 also displays excellent efficacy in a transgenic mouse model of induced pain . MCE has not independently confirmed the accuracy of these methods. They are for reference only. IC50& Target:Na v 1.7 3 nM (IC 50 )

GNE-131 是一种强效的人类钠通道 NaV1.7 选择性抑制剂，其 IC 50 为 3 nM。

1629063-81-5(DMSO)

C23H30N4O3S

442.57 g/mol

C1CC1C2=CN3C(=NN=C3NS(=O)(=O)C4CC4)C=C2OCC56CC7CC(C5)CC(C7)C6

抑制剂

Na 抑制剂 v1.1；Na 抑制剂 v1.2；Na 抑制剂 v1.5；Na 抑制剂 v1.6；Na 抑制剂 v1.7