GSK2850163

GSK2850163

G656144-1ml

1ml

10mM in DMSO

-80℃储存

超低温冰袋运输

GSK2850163 is a novel inhibitor of inositol-requiring enzyme-1 alpha ( IRE1α ) which can inhibit IRE1α kinase activity and RNase activity with IC 50 s of 20 and 200 nM, respectively. In Vitro GSK2850163 is a novel inhibitor of inositol-requiring enzyme-1 alpha (IRE1α) which can inhibit IRE1α kinase activity and RNase activity with IC 50 s of 20 and 200 nM, respectively. The increased autophosphorylation of IRE1α could be reduced in a dose-dependent manner by GSK2850163. Increasing concentrations of GSK2850163 are capable of reducing the increased XBP 1 transcriptional activity. Two additional kinases are weakly inhibited by GSK2850163: Ron (IC 50 =4.4 μM) and FGFR1 V561M (IC 50 =17 μM). MCE has not independently confirmed the accuracy of these methods. They are for reference only. IC50& Target:IC50: 20 nM (IRE1α kinase activity), 200 nM (IRE1α RNase activity)

GSK2850163 是一种新型的肌醇需要酶-1α（IRE1α）抑制剂，可抑制 IRE1α 激酶活性和 RNase 活性，IC 50 s 分别为 20 和 200 nM。

2121989-91-9(DMSO)

C24H29Cl2N3O

446.41 g/mol

CC1=CC=C(C=C1)CNC(=O)N2CCCC3(C2)CCN(C3)CC4=CC(=C(C=C4)Cl)Cl