GAK inhibitor 49 hydrochloride

GAK 抑制剂 49 盐酸盐

GAK inhibitor 49 hydrochloride

G659460-5mg

5mg

≥98%

2-8°C储存,干燥

冰袋运输

GAK inhibitor 49 hydrochloride is a potent, ATP-competitive and highly selective cyclin G associated kinase (GAK) inhibitor with a K i of 0.54 nM and a cell IC 50 of 56 nM. GAK inhibitor 49 hydrochloride also shows binding to RIPK2. Appearance:Solid In Vitro:GAK inhibitor 49 (compound 49) hydrochloride shows a weak inhibitory effect on AAK1, BMP2K and STK16, with IC 50 s of 28, 63 and >100μM, respectively. MCE has not independently confirmed the accuracy of these methods. They are for reference only. Biological Activity:GAK inhibitor 49 hydrochloride is a potent, ATP-competitive and highly selective cyclin G associated kinase (GAK) inhibitor with a K i of 0.54 nM and a cell IC 50 of 56 nM. GAK inhibitor 49 hydrochloride also shows binding to RIPK2.

C20H23ClN2O5

406.86 g/mol

COC1=C(OC)C(OC)=CC(NC2=CC=NC3=CC(OC)=C(OC)C=C23)=C1.[H]Cl

DMSO : 14.29 mg/mL (35.12 mM; Need ultrasonic)