GSK761

GSK761

G659464-5mg

5mg

≥99%

-20°C储存

超低温冰袋运输

GSK761 is a selective inhibitor of speckled 140 kDa (SP140) with an IC 50 value of 77.79 nM. GSK761 reduces monocyte-to-inflammatory macrophage differentiation and lipopolysaccharide (LPS)-induced inflammatory activation. GSK761 induces the production of Appearance:Solid IC50& Target:IC50: 77.79 nM (Speckled 140 kDa, SP140) In Vitro:GSK761 combines with SP140 in HuT78 cells and HEK293 cells transfected with Halo-tagged SP140. GSK761 (0.01-1.11 µM; 1 h) reduces the inflammatory activation and down-regulates the expression of TNF, IL-6, IL-12p70, IL-1β, IL-8, IL-10 pro-inflammator Biological Activity:GSK761 is a selective inhibitor of speckled 140 kDa (SP140) with an IC 50 value of 77.79 nM. GSK761 reduces monocyte-to-inflammatory macrophage differentiation and lipopolysaccharide (LPS)-induced inflammatory activation. GSK761 induces the production of

C40H46N4O4

646.82 g/mol

CN1C2=CC=C(C=C2N=C1C3=CC=C(C=C3)C(NC4=CC(CCOC(C)(C)C)=CC=C4)=O)C(NC5=CC(CCOC(C)(C)C)=CC=C5)=O

DMSO : 125 mg/mL (193.25 mM; ultrasonic and warming and heat to 60°C)