GSK 690 Hydrochloride

GSK 690 盐酸盐

GSK 690 Hydrochloride

G661638-1ml

1ml

10mM in DMSO

干燥,-80℃储存

超低温冰袋运输

GSK 690 (Hydrochloride) is a reversible inhibitor of lysine specific demethylase 1 (LSD1) , with a K d value of 9 nM and a biochemical IC 50 of 37 nM. IC50& Target:IC50: 37 nM (LSD1), Kd: 8 nM (LSD1) . In Vitro:GSK690 (1-10 μM) acts together with JNJ-26481585 to induce cell death in all four tested RMS cells lines (RD, RH30, RMS13, and TE381.T cells). GSK690/JNJ-26481585 cotreatment alters the balance between pro- and antiapoptotic proteins with 1 μM GSK690 Biological Activity:GSK 690 (Hydrochloride) is a reversible inhibitor of lysine specific demethylase 1 (LSD1) , with a K d value of 9 nM and a biochemical IC 50 of 37 nM.

C24H24ClN3O

405.92 g/mol

N#CC1=CC=C(C2=CC(OC[C@H]3CNCC3)=CN=C2C4=CC=C(C)C=C4)C=C1.Cl