GB-110 hydrochloride

GB-110盐酸盐

GB-110 hydrochloride

G661669-1ml

1ml

10mM in DMSO

干燥,-80℃储存

超低温冰袋运输

GB-110 hydrochloride is a potent, orally active, and nonpeptidic protease activated receptor 2 (PAR2) agonist. GB-110 hydrochloride selectively induces PAR2-mediated intracellular Ca 2+ release in HT29 cells with an EC 50 of 0.28 μM. IC50& Target:PAR2 In Vitro:In an intracellular Ca 2+ (iCa 2+ ) mobilization assay using HT29 colon cancer cells, GB110 (EC 50 240±20 nM; pEC 50 6.7±0.05) is equipotent with the peptide agonist 2f-LIGRLO-NH2 (EC 50 210±30 nM; pEC 50 6.6±0.05), 10-fold more potent than SLIGRL-NH2, bu Biological Activity:GB-110 hydrochloride is a potent, orally active, and nonpeptidic protease activated receptor 2 (PAR2) agonist. GB-110 hydrochloride selectively induces PAR2-mediated intracellular Ca 2+ release in HT29 cells with an EC 50 of 0.28 μM.

C33H49ClN6O5

645.23 g/mol

O=C(C1=CC=NO1)N[C@@H](CC2CCCCC2)C(N[C@@H]([C@@H](C)CC)C(NCC3=CC=CC(C(N4CCC(CN)CC4)=O)=C3)=O)=O.Cl