GSK598809 is a potent and selective dopamine D3 Receptor (DRD3) antagonist, with a pK i of 8.9. In Vivo Cocaine and GSK598809 each increases peak mean arterial blood pressure. Least square mean differences are significant for both doses of cocaine compared with its vehicle. Likewise, least square mean differences are significant for both doses of GSK598809 as compared with its vehicle. The experimental question of interest, that is, whether GSK598809 significantly increases cocaine effects on peak mean arterial blood pressure, is probed by a prior it tests on the means of the fitted regression model. The dose of 3 mg/kg GSK598809 significantly increases the pressor effects of 5.6 mg/kg cocaine and of 1.7 mg/kg cocaine . MCE has not independently confirmed the accuracy of these methods. They are for reference only. Form:Solid IC50& Target:pKi: DRD3