H-1152是特异的高活性Rho激酶抑制剂，可渗透入细胞膜，Ki为1.6 nM，对其它丝氨酸/苏氨酸激酶抑制性极低。A cell permeable, highly specific, and potent ATP-competitive inhibitor of ρ-kinase inhibitor。 H-1152, an isoquinolinesulfonamide derivative, is a more specific, stronger and membrane-permeable inhibitor of Rho-kinase with a Ki value of 1.6 nM, but poor inhibitor of other serine/threonine kinases. A cell permeable, highly specific, and potent ATP-competitive inhibitor of ρ-kinase inhibitor。