5-HT1AR agonist 1

5-HT1AR agonist 1

H1428465-1mg

1mg

5-HT1AR agonist 1 (Compound A3) emerges as a relatively balanced multi-target activity profile, including 5-HT1AR agonist with an EC 50 value of 34 nM, SERT reuptake ihibitor ( IC 50 =12 nM), NET reuptake inhibitor ( IC 50 =78 nM) and DAT reuptake inhibitor ( IC 50 =135 nM). 5-HT1AR agonist 1 performs significant antidepressant effects and exhibits excellent bioavailability and low clearance in mice, which is promising for research in the field of antidepressant drugs.