HSP27 inhibitor J2

小分子

HSP27 抑制剂 J2

HSP27 inhibitor J2

H650076-5mg

5mg

≥99%

-20°C储存

超低温冰袋运输

HSP27 inhibitor J2 (J2) is a HSP27 inhibitor, which significantly induces abnormal HSP27 dimer formation and inhibits a production of HSP27 giant polymers , thereby having an effect of inhibiting a chaperone function of the HSP27 and reducing a cell protection function thereof. HSP27 inhibitor J2 (J2) remarkably enhances the antiproliferative activity of 17-AAG and sensitizes cisplatin-induced lung cancer cell growth inhibition In Vitro HSP27 inhibitor J2 (10 μM; 12 h) induces significant abnormal HSP27 dimer formation in NCI-H460. ?\nHSP27 inhibitor J2 (10 μM; 24 h) increases 17-AAG-induced apoptosis in shCTRL cells. MCE has not independently confirmed the accuracy of these methods. They are for reference only. Form:Solid IC50& Target:HSP27

HSP27 抑制剂 J2（J2）是一种 HSP27 抑制剂，它能显著诱导 HSP27 二聚体的异常形成并抑制 HSP27 巨型聚合物的产生，从而具有抑制 HSP27 的伴侣功能和减少细胞蛋白的作用。

2133499-85-9

C13H12O4S

264.3 g/mol

135384973

CC1=CC(=O)C2=C(C=C(C=C2O1)OCC3CS3)O

5-hydroxy-2-methyl-7-(thiiran-2-ylmethoxy)chromen-4-one

1S/C13H12O4S/c1-7-2-10(14)13-11(15)3-8(4-12(13)17-7)16-5-9-6-18-9/h2-4,9,15H,5-6H2,1H3

VDCWAGBPDCXRDU-UHFFFAOYSA-N

CC1=CC(=O)C2=C(C=C(C=C2O1)OCC3CS3)O

135384973

DMSO : 20 mg/mL (75.67 mM; Need ultrasonic)

1

5

3

264.046 Da

264.046 Da

81.100 Ų

18

0

381.000

0

1

1.600