HM03

小分子

HM03

H651975-5mg

5mg

≥99%

-20°C储存

超低温冰袋运输

HM03 is a potent and selective HSPA5 (Heat shock 70kDa protein 5, also known as Bip, Grp78) inhibitor. HM03 has anticancer activity In Vitro HM03 (0.1-50 μM; 72 hours) exhibits over 50% inhibition at 25 μM concentration in HCT116 cells. ?\nHM03 forms more binding interactions with HSPA5 and HSPA9 than with the other HSP70 proteins. ?\nHM03 exhibits promising inhibition activities from cancer cell viability and tumor inhibition assays. MCE has not independently confirmed the accuracy of these methods. They are for reference only. Cell Viability AssayCell Line: HCT116 cells Concentration: 0.1, 1, 10, 25, 50 μM Incubation Time: 72 hours Result: Exhibited prominent inhibition effect (18% survival at 25 µM). Form:Solid IC50& Target:HSPA5

HM03 是一种强效的选择性 HSPA5（热休克 70kDa 蛋白 5，又称 Bip、GRP78）抑制剂。HM03 具有抗癌活性。

500565-15-1

C26H27ClN4O2

462.97 g/mol

421105

CN1CCN(CC1)CC2=C(C=CC(=C2)NC3=C4C=C(C=CC4=NC5=C3C=CC(=C5)Cl)OC)O

4-[(6-chloro-2-methoxyacridin-9-yl)amino]-2-[(4-methylpiperazin-1-yl)methyl]phenol

1S/C26H27ClN4O2/c1-30-9-11-31(12-10-30)16-17-13-19(4-8-25(17)32)28-26-21-6-3-18(27)14-24(21)29-23-7-5-20(33-2)15-22(23)26/h3-8,13-15,32H,9-12,16H2,1-2H3,(H,28,29)

SUSDGTMJKOGWSZ-UHFFFAOYSA-N

CN1CCN(CC1)CC2=C(C=CC(=C2)NC3=C4C=C(C=CC4=NC5=C3C=CC(=C5)Cl)OC)O

421105

DMSO : 125 mg/mL (270.00 mM; Need ultrasonic)

2

6

5

462.182 Da

462.182 Da

60.900 Ų

33

0

633.000

0

1

5.000