HDAC8-IN-1 is a HDAC8 inhibitor with an IC 50 of 27.2 nM. In Vitro HDAC8-IN-1 is a HDAC8 inhibitor with an IC 50 of 27.2 nM in cancer cell lines. HDAC8-IN-1 (compound 22 d) shows antiproliferative effects toward several human lung cancer cell lines (A549, H1299, and CL1-5); HDAC8-IN-1 exhibits cytotoxicity against human lung CL1-5 cells without significant cytotoxicity for normal IMR-90 cells. MCE has not independently confirmed the accuracy of these methods. They are for reference only. Form:Solid IC50& Target:HDAC8 27.2 nM (IC 50 )