欧前胡素

小分子

前胡内酯 | 白芷乙素 | 前胡素 | 8-(3-甲基-2-丁烯氧基)补骨脂素 | 8-异戊烯氧基补骨脂素 | 白茅苷 | 9-[(3-甲基-2-丁烯-1-基)氧]-7H-呋喃并[3,2-g]色满-7-酮 | 主人草素 | 欧芹属素乙 | 9-((3-甲基丁-2-烯-1-基)氧基)-7H-呋喃[3,2-g]苯并吡喃-7-酮

8-Isopentenyloxypsoralene | Marmelosin | Pentosalen | 9-(3-Methylbut-2-enyloxy)furo(3,2-g)chromen-7-one | 9-(3-methylbut-2-enoxy)furo[3,2-g]chromen-7-one | HSDB 3497 | NSC 402949 | 8-Isoamylenoxypsoralen | CCRIS 4346 | Ammidin | Marmelide

Imperatorin

I114064-100mg

100mg

Moligand™

≥98%(HPLC)

-20°C储存

超低温冰袋运输

对热敏感

属呋喃香豆素类化合物。为棱柱状结晶（由乙醚）、长细针晶（由热水），易溶于氯仿，可溶于苯、乙醇、乙醚和苛性碱溶液，不溶于冷水。 Imperatorin is a furocoumarin present in citrus fruits, which is used in HIV-1 research. Studies indicate that the transcription factor Sp1 is essential in the inhibitory functions of Imperatorin. In addition, Imperatorin inhibits cyclin D1 expression and stops the cell cycle at G1. These studies also sμggest that Imperatorin suppresses HIV-1 replication in primary T lymphocytes and transformed cell lines. Furthermore, it has been sμggested that the inhibitory effects of Imperatorin on HIV-1 at the transcriptional level can be monitored effectively in HeLa cells. Imperatorin can also cause apoptosis in human promyelocytic leukaemia, HL-60 via the cytochrome c/caspase-9 pathway. Imperatorin is a furocoumarin present in citrus fruits, which is used in HIV-1 research. Studies indicate that the transcription factor Sp1 is essential in the inhibitory functions of Imperatorin. In addition, Imperatorin inhibits cyclin D1 expression and stops the cell cycle at G1. These studies also suggest that Imperatorin suppresses HIV-1 replication in primary T lymphocytes and transformed cell lines. Furthermore, it has been suggested that the inhibitory effects of Imperatorin on HIV-1 at the transcriptional level can be monitored effectively in HeLa cells. Imperatorin can also cause apoptosis in human promyelocytic leukaemia, HL-60 via the cytochrome c/caspase-9 pathway.

欧前胡素是p38、ERK路径的调控因子。欧前胡素增加BMP-2的表达(mRNA) ,体外研究证实欧前胡素增加体内骨质密度/体积和矿物化。细胞周期蛋白D1抑制剂。诱导细胞周期停滞在G1。激活胱天蛋白酶9并诱导凋亡。抑制HIV-1复制。TRPV1激动剂弱（EC 50 = 13μM）。显示出抗增殖作用。在体内显示镇痛作用。

482-44-0

C16H14O4

270.28 g/mol

207-581-1

MFCD00016881

10212

CC(=CCOC1=C2C(=CC3=C1OC=C3)C=CC(=O)O2)C

9-(3-methylbut-2-enoxy)furo[3,2-g]chromen-7-one

1S/C16H14O4/c1-10(2)5-7-19-16-14-12(6-8-18-14)9-11-3-4-13(17)20-15(11)16/h3-6,8-9H,7H2,1-2H3

OLOOJGVNMBJLLR-UHFFFAOYSA-N

CC(=CCOC1=C2C(=CC3=C1OC=C3)C=CC(=O)O2)C

Soluble in DMSO (≥5 mg/ml), methanol, DMF, and water (slightly). Insoluble in ethanol.

97.0 to 101.0 °C

0

4

3

270.089 Da

270.089 Da

48.700 Ų

20

0

436

0

1

3.4

1.242

249728

4925

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