IMP-1088

未知

IMP-1088

I647608-5mg

5mg

≥98%

-20°C储存

超低温冰袋运输

IMP-1088 is a potent human N-myristoyltransferases NMT1 and NMT2 dual inhibitor with IC 50 s of In Vitro IMP-1088 (1-1000 nM) prevents virus-induced cytopathic effect (CPE) in a dose-dependent manner with an IC 50 of 17 nM. IMP-1088 (125 nM) complete suppresses of new infectious virus with an IC 50 of 5.8 nM. IMP-1088 (1-1000 nM) blocks production of infectious virus and inhibits single cycle replication in primary human bronchial epithelial cells (hBEC) infected with rhinovirus RV-A1 (MOI 5) for 7 h. IMP-1088 significantly inhibits production of infectious virus even when added up to 3 hours post-infection. IMP-1088 (50 nM) significantly less enriches multiple N-myristoylated proteins in enriched samples. IMP-1088 (500 nM) inhibits production of infectious rhinovirus particles by blocking virus assembly in HeLa cells infected with rhinovirus RV-A16 (MOI 20) for 6 h. IMP-1088 (0.24 nM-1 µM; for 24 hours +24 hours washout) has no long-term effect on cell viability and NMT activity fully recovers by 24 h. IMP-1088 potently blocks a key step in viral capsid assembly by inhibition of co-translational myristoylation of a specific virus-encoded protein (VP0). IMP-1088 blocks neither production of viral RNA, nor translation of rhinovirus polyprotein. MCE has not independently confirmed the accuracy of these methods. They are for reference only. Form:Liquid IC50& Target:IC50:

IMP-1088 是一种强效的人类 N-肉豆蔻酰转移酶 NMT1 和 NMT2 双重抑制剂，对 HsNMT1 和 HsNMT2 的 IC 50 s 均小于 1 nM。IMP-1088 对 HsNMT1 的 K d 小于 210 pM。IMP-1088 通过阻断鼻病毒编码的鼻病毒基因，有效阻断鼻病毒的复制。

2059148-82-0

C25H29F2N5O

453.53 g/mol

132274735

CC1=C(C(=NN1C)C)CCOC2=C(C=CC(=C2F)F)C3=CC4=C(C=C3)N(N=C4CN(C)C)C

CC1=C(C(=NN1C)C)CCOC2=C(C=CC(=C2F)F)C3=CC4=C(C=C3)N(N=C4CN(C)C)C

132274735

DMSO : 100 mg/mL (220.49 mM; Need ultrasonic)

0

6

7

453.234 Da

453.234 Da

48.100 Ų

33

0

642.000

0

1

4.300