ICAM-1-IN-1

小分子

细胞间粘附分子-1-合-1

ICAM-1-IN-1

I649334-5mg

5mg

≥99%

-20°C储存

超低温冰袋运输

ICAM-1-IN-1 is a potent and selective inhibitor of E-selectin and ICAM-1 with IC 50 values of 7 and 5 nM, respectively. In Vivo ICAM-1-IN-1 shows significant efficacy in a rat rheumatoid arthritis model and in a mouse asthma model. ICAM-1-IN-1 reduces the width of inflamed ankles after the ninth day following treatment, but shows no efficacy in the acute phase. Treatment with ICAM-1-IN-1 (25 mg/kg) for 21 days significantly reduces the ankle inflammation of the arthritis rats. Significant reduction of eosinophils and serum-soluble ICAM-1 (sICAM-1) is observed . MCE has not independently confirmed the accuracy of these methods. They are for reference only. Form:Solid IC50& Target:IC50: 7 nM (E-selectin), 5 nM (ICAM-1)

ICAM-1-IN-1 是一种强效的 E-选择素和 ICAM-1 选择性抑制剂，IC50 值分别为 7 和 5 nM。

251994-14-6

C15H11BrN2O2S

363.23 g/mol

10361323

CNC(=O)C1=CC2=C(S1)C=NC=C2OC3=CC=C(C=C3)Br

4-(4-bromophenoxy)-N-methylthieno[2,3-c]pyridine-2-carboxamide

1S/C15H11BrN2O2S/c1-17-15(19)13-6-11-12(7-18-8-14(11)21-13)20-10-4-2-9(16)3-5-10/h2-8H,1H3,(H,17,19)

OFXAEWYLVPBGGU-UHFFFAOYSA-N

CNC(=O)C1=CC2=C(S1)C=NC=C2OC3=CC=C(C=C3)Br

10361323

DMSO : ≥ 135 mg/mL (371.67 mM)

1

4

3

361.972 Da

361.972 Da

79.500 Ų

21

0

377.000

0

1

3.700