IDH889

小分子

IDH889

I650995-5mg

5mg

≥98%

-20°C储存

超低温冰袋运输

IDH889 is an orally available, brain penetrant, allosteric and mutant specific inhibitor of isocitrate dehydrogenase 1 (IDH1) . IDH889 has potent selectivity for IDH1 R132* mutations, with IC 50 s of 0.02 μM, 0.072 μM and 1.38 μM for IDH1 R132H , IDH1 R132C and IDH1 wt , respectively. IDH889 shows potent cellular inhibition of R-2-hydroxyglutarate (2-HG) production with an IC 50 of 0.014 μM Form:Solid IC50& Target:IC50: 0.02 μM (IDH1 R132H ), 0.072 μM (IDH1 R132C ), 1.38 μM (IDH1 wt )

IDH889 是异柠檬酸脱氢酶 1（IDH1）的一种口服、脑穿透、异位和突变特异性抑制剂。IDH889 对 IDH1 R132* 突变具有强效选择性，对 IDH1 R132H、IDH1 R132H 和 IDH1 R132* 突变的 IC 50 s 分别为 0.02 μM、0.072 μM 和 1.38 μM。

1429179-07-6

C23H25FN6O2

436.48 g/mol

71542286

CC1=C(C=CC(=C1)C2=CN=C(N=C2)[C@H](C)NC3=NC=CC(=N3)N4[C@H](COC4=O)C(C)C)F

(4S)-3-[2-[[(1S)-1-[5-(4-fluoro-3-methylphenyl)pyrimidin-2-yl]ethyl]amino]pyrimidin-4-yl]-4-propan-2-yl-1,3-oxazolidin-2-one

1S/C23H25FN6O2/c1-13(2)19-12-32-23(31)30(19)20-7-8-25-22(29-20)28-15(4)21-26-10-17(11-27-21)16-5-6-18(24)14(3)9-16/h5-11,13,15,19H,12H2,1-4H3,(H,25,28,29)/t15-,19+/m0/s1

JDCYIMQAIKEACU-HNAYVOBHSA-N

CC1=C(C=CC(=C1)C2=CN=C(N=C2)C(C)NC3=NC=CC(=N3)N4C(COC4=O)C(C)C)F

71542286

DMSO : 200 mg/mL (458.21 mM; Need ultrasonic)

1

8

6

436.202 Da

436.202 Da

93.100 Ų

32

0

632.000

0

1

4.100