INO-1001

小分子

N-(3-Morpholinopropyl)-5-oxo-6,11-dihydro-5H-indeno[1,2-c]isoquinoline-9-sulfonamide | HY-15045 | INO-1001 free base | BDBM27525 | 5H-Indeno(1,2-C)isoquinoline-9-sulfonamide, 6,11-dihydro-N-(3-(4-morpholinyl)propyl)-5-oxo- | UNII-343SLZ0F89 | 5H-Indeno[1,

INO-1001

I651235-5mg

5mg

≥98%

-20°C储存

超低温冰袋运输

INO-1001 is a potent and selective poly (ADP-ribose) polymerase (PARP) inhibitor. INO-1001 is a potent enhancer of radiation sensitivity and enhances radiation-induced cell killing by interfering with DNA repair mechanisms, resulting in necrotic cell death INO-1001 has anti-tumor effects . In Vitro INO-1001 has an IC 50 of 0.05 μM in Chinese hamster ovary AA8 (CHO) cells. MCE has not independently confirmed the accuracy of these methods. They are for reference only. Form:Solid IC50& Target:PARP

INO-1001 是一种强效的选择性聚（ADP-核糖）聚合酶（PARP）抑制剂。INO-1001 能有效增强辐射敏感性，并通过干扰 DNA 修复机制增强辐射诱导的细胞杀伤力，导致坏死细胞死亡。

501364-82-5

C23H25N3O4S

439.5 g/mol

9889396

C1COCCN1CCCNS(=O)(=O)C2=CC3=C(C=C2)C4=C(C3)C5=CC=CC=C5C(=O)N4

N-(3-morpholin-4-ylpropyl)-5-oxo-6,11-dihydroindeno[1,2-c]isoquinoline-9-sulfonamide

1S/C23H25N3O4S/c27-23-20-5-2-1-4-19(20)21-15-16-14-17(6-7-18(16)22(21)25-23)31(28,29)24-8-3-9-26-10-12-30-13-11-26/h1-2,4-7,14,24H,3,8-13,15H2,(H,25,27)

LTZVLHHIAUKGBP-UHFFFAOYSA-N

C1COCCN1CCCNS(=O)(=O)C2=CC3=C(C=C2)C4=C(C3)C5=CC=CC=C5C(=O)N4

9889396

DMSO : 31.25 mg/mL (71.10 mM; Need ultrasonic)

2

6

6

439.157 Da

439.157 Da

96.100 Ų

31

0

815.000

0

1

1.500