INCB059872 dihydrochloride

INCB059872 二盐酸盐

INCB059872 dihydrochloride

I659229-5mg

5mg

≥98%

2-8°C储存,干燥

冰袋运输

INCB059872 dihydrochloride is a potent, orally active, selective and irreversible Lysine-Specific Demethylase 1 ( LSD1 ) inhibitor. INCB059872 dihydrochloride can be used for the research of myeloid leukemia. Appearance:Solid IC50& Target:KDM1/LSD1 In Vitro:INCB059872 (25 nM; 48 hours; 293T cells) dihydrochloride increases enhancer activity and gene expression. INCB059872 (25 nM; 24 hours; THP-1 cells) dihydrochloride makes THP-1 show a growth defect within one cell doubling time or approximately 3 days In Vivo:INCB059872 (10mg/kg; p.o.; 0, 4, or 6 days; C57BL/6J mice) dihydrochloride makes single-cell RNA-seq revealing changes in bone marrow progenitor populations. MCE has not independently confirmed the accuracy of these methods. They are for reference o Biological Activity:INCB059872 dihydrochloride is a potent, orally active, selective and irreversible Lysine-Specific Demethylase 1 ( LSD1 ) inhibitor. INCB059872 dihydrochloride can be used for the research of myeloid leukemia.

C23H36Cl2N2O3

459.45 g/mol

OC(C1(CCC1)CN2CCC(COC)(CC2)CN[C@H]3[C@@](C4=CC=CC=C4)([H])C3)=O.[H]Cl.[H]Cl

DMSO : 3.57 mg/mL (7.77 mM; ultrasonic and warming and heat to 60°C)