K-Ras G12C-IN-3

1-[4-[(2',5',6-Trichloro-4-methoxy[1,1'-biphenyl]-3-yl)carbonyl]-1-piperazinyl]-2-propen-1-one | HY-18606 | 1-[4-[4-chloro-5-(2,5-dichlorophenyl)-2-methoxybenzoyl]piperazin-1-yl]prop-2-en-1-one | A911093 | DTXSID901118534 | 1629268-19-4 | 1-(4-(2',5',6-tr

K-Ras G12C-IN-3

K646591-5mg

5mg

≥99%

-20°C储存

超低温冰袋运输

K-Ras G12C-IN-3 is a novel and irreversible inhibitor of mutant K-ras G12C.IC50 value:Target: K-ras G12C inhibitorFor more information, please see the following patent.Heterocyclic compounds as covalent inhibitors of G12C mutant K-Ras protein useful for treating cancers, and preparation thereofBy Ren, Pingda; Liu, Yi; Li, Liansheng; Feng, Jun; Wu, TaoFrom PCT Int. Appl. (2014), WO 2014152588 A1 20140925. Form:Solid

K-Ras G12C-IN-3 是一种新型不可逆的突变 K-ras G12C 抑制剂：更多信息，请参阅以下专利：\nHeterocyclic compounds as covalent inhibitors of G12C mutant K-Ras protein usef

1629268-19-4

C21H19Cl3N2O3

453.75 g/mol

92044410

COC1=C(C=C(C(=C1)Cl)C2=C(C=CC(=C2)Cl)Cl)C(=O)N3CCN(CC3)C(=O)C=C

1-[4-[4-chloro-5-(2,5-dichlorophenyl)-2-methoxybenzoyl]piperazin-1-yl]prop-2-en-1-one

1S/C21H19Cl3N2O3/c1-3-20(27)25-6-8-26(9-7-25)21(28)16-11-15(18(24)12-19(16)29-2)14-10-13(22)4-5-17(14)23/h3-5,10-12H,1,6-9H2,2H3

RPBHAPLCWWQJAK-UHFFFAOYSA-N

COC1=C(C=C(C(=C1)Cl)C2=C(C=CC(=C2)Cl)Cl)C(=O)N3CCN(CC3)C(=O)C=C

92044410

1629268-19-4

DMSO : ≥ 30 mg/mL (66.12 mM)

0

3

4

452.046 Da

452.046 Da

49.900 Ų

29

0

612.000

0

1

4.700